Angiotensin II Receptor: Molecular Cloning, Functions, and Regulation.
نویسندگان
چکیده
منابع مشابه
Molecular cloning, characterization, and distribution of the gerbil angiotensin II AT2 receptor.
We isolated a cDNA clone encoding the gerbil AT2 receptor (gAT2) gene from a gerbil adrenal gland cDNA library. The full-length cDNA contains a 1,089-bp open reading frame encoding 363 amino acid residues with 90.9, 96.1, and 95.6% identity with the human (hAT2), rat (rAT2), and mouse AT2 (mAT2) receptors, respectively. There are at least seven nonconserved amino acids in the NH2-terminal domai...
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The renin-angiotensin system (RAS) plays a critical role in cardiovascular and fluid homeostasis. The major biologically active peptide of the RAS is angiotensin II, which acts through G protein-coupled receptors of two pharmacological classes, AT(1) and AT(2). AT(1) receptors, expressed in brain and peripheral tissues, mediate most classically recognized actions of the RAS, including blood pre...
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ژورنال
عنوان ژورنال: Hypertension Research
سال: 1994
ISSN: 0916-9636,1348-4214
DOI: 10.1291/hypres.17.87